<!DOCTYPE html>
<html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-0 vector-toc-not-available vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-0 skin-theme-clientpref-day vector-sticky-header-enabled" lang="de" dir="ltr"><head>
<meta charset="UTF-8">
<title>David Cushman</title>
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<link rel="icon" type="image/png" href="./_res_/favicon.png">
<link rel="canonical" href="https://de.wikipedia.org/wiki/David_Cushman"> <link href="./_mw_/ext.cite.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.wikimediamessages.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.icons.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.search.codex.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.styles.css" rel="stylesheet" type="text/css">
<meta name="ResourceLoaderDynamicStyles" content="">
<link href="./_mw_/ext.gadget.citeRef.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.defaultPlainlinks.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonHide.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonLayout.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonStyle.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiDarkmode.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiResponsive.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.specialSearch.css" rel="stylesheet" type="text/css">
<link rel="stylesheet" type="text/css" href="./_mw_/site.styles.css">
<link rel="stylesheet" type="text/css" href="./_mw_/noscript.css">
<link rel="stylesheet" type="text/css" href="./_res_/footer.css">
<link rel="stylesheet" type="text/css" href="./_res_/vector-2022.css">
</head>
<body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject page-David_Cushman rootpage-David_Cushman skin-vector-2022 action-view">
<div class="mw-page-container">
<div class="mw-page-container-inner">
<div class="mw-content-container">
<main id="content" class="mw-body">
<header class="mw-body-header vector-page-titlebar">
<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">David Cushman</span></h1>
</header>
<a id="top"></a>
<div id="bodyContent" class="vector-body ve-init-mw-desktopArticleTarget-targetContainer" aria-labelledby="firstHeading" data-mw-ve-target-container="">
<div id="contentSub">
<div id="mw-content-subtitle"></div>
</div>
<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p><b>David W. Cushman</b> (* <a href="15._November" title="15. November">15. November</a> <a href="1939" title="1939">1939</a>; † <a href="14._August" title="14. August">14. August</a> <a href="2000" title="2000">2000</a>) war ein <a href="Vereinigte_Staaten" title="Vereinigte Staaten">US-amerikanischer</a> <a href="Biochemiker" class="mw-redirect" title="Biochemiker">Biochemiker</a>. Er entwickelte mit <a href="Miguel_Ondetti" title="Miguel Ondetti">Miguel Ondetti</a> <a href="Captopril" title="Captopril">Captopril</a> den ersten <a href="ACE-Hemmer" title="ACE-Hemmer">ACE-Hemmer</a>. Dies war gleichzeitig eines der ersten Beispiele <a href="Rationales_Design" title="Rationales Design">rationalen Medikamentendesigns</a>.
</p><p>Cushman wurde 1966 bei <a href="Irwin_C._Gunsalus" title="Irwin C. Gunsalus">Irwin C. Gunsalus</a> mit dem Thema <i>Methylene Hydroxylase Monooxygenases: Components and Properties of 2-Bornanone 5-Exo-Hydroxylase</i> an der <a href="University_of_Illinois_at_Urbana-Champaign" title="University of Illinois at Urbana-Champaign">University of Illinois at Urbana-Champaign</a> in Biochemie <a href="Promotion_(Doktor)" title="Promotion (Doktor)">promoviert</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> und war dann ab 1968 am <a href="Bristol-Myers_Squibb" title="Bristol-Myers Squibb">Squibb</a>-Forschungsinstitut (Squibb Institute of Medical Research). 1974 entwickelte er dort mit Ondetti Captopril. Es wurde 1981 von der FDA zugelassen.
</p><p>1992 erhielt er mit Miguel Ondetti den <a href="ACS_Award_for_Creative_Invention" title="ACS Award for Creative Invention">ACS Award for Creative Invention</a> der <a href="American_Chemical_Society" title="American Chemical Society">American Chemical Society</a>. 2007 wurde Cushman in die <a href="National_Inventors_Hall_of_Fame_(Auszeichnung)" class="mw-redirect" title="National Inventors Hall of Fame (Auszeichnung)">National Inventors Hall of Fame</a> aufgenommen. 1999 erhielt er mit Ondetti den <a href="Lasker~DeBakey_Clinical_Medical_Research_Award" title="Lasker~DeBakey Clinical Medical Research Award">Lasker~DeBakey Clinical Medical Research Award</a> und 1982 erhielten beide den GlaxoSmithKline Alfred Burger Award<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>. 1991 wurde Cushman mit dem <a href="Warren_Alpert_Foundation_Prize" title="Warren Alpert Foundation Prize">Warren Alpert Foundation Prize</a> ausgezeichnet.
</p>
<div class="mw-heading mw-heading2"><h2 id="Schriften">Schriften</h2></div>
<ul><li>mit B. Rubin, M. Ondetti: Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents, Science, Band 196, 1977, S. 441–444.</li></ul>
<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>
<ul><li><a rel="nofollow" class="external text" href="http://www.chemheritage.org/discover/online-resources/chemistry-in-history/themes/pharmaceuticals/restoring-and-regulating-the-bodys-biochemistry/ondetti.aspx">Chemical Heritage Foundation</a></li>
<li><a rel="nofollow" class="external text" href="http://www.laskerfoundation.org/awards/1999_c_description.htm">Lasker Foundation zum Preis für Cushman/Ondetti</a></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://academictree.org/chemistry/peopleinfo.php?pid=98531">Informationen</a> zu und <a rel="nofollow" class="external text" href="https://academictree.org/chemistry/tree.php?pid=98531">akademischer Stammbaum</a> von <i>David W. Cushman</i> bei academictree.org, abgerufen am 28. Januar 2018.<span class="editoronly" style="display:none;"></span></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.acsmedchem.org/cushman.html">ACS Medicinal Chemistry Hall of Fame</a></span>
</li>
</ol>
<div class="hintergrundfarbe1 rahmenfarbe1 navigation-not-searchable normdaten-typ-p" style="border-style: solid; border-width: 1px; clear: left; margin-bottom:1em; margin-top:1em; padding: 0.25em; overflow: hidden; word-break: break-word; word-wrap: break-word;" id="normdaten">
<div style="display: table-cell; vertical-align: middle; width: 100%;">
<div>
Normdaten (Person): <a href="Library_of_Congress_Control_Number" title="Library of Congress Control Number">LCCN</a>: <span class="-print"><a rel="nofollow" class="external text" href="https://id.loc.gov/authorities/n96801435">n96801435</a></span> | <a href="Virtual_International_Authority_File" title="Virtual International Authority File">VIAF</a>: <span class="-print"><a rel="nofollow" class="external text" href="https://viaf.org/viaf/14045946/">14045946</a></span> | </div>
</div></div>
</div><!--htdig_noindex--><div><div class="zim-footer">
Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2025-12-03" href="https://de.wikipedia.org/wiki/?title=David_Cushman&oldid=262087872">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.
</div>
</div><!--/htdig_noindex--></div>
</div>
</main>
</div>
</div>
</div>
<script src="./_webp_/webpHandler.js"></script>
</body></html>